2021-2022 Volleyball Schedule
| DATE | OPPONENT | TIME | LOCATION |
| August 31 | Triad (Fr-JV-V) | 5:00 p.m. Fr 5:00 p.m. JV-V | Away. Freshman lost, JV and Varsity both won in Triad |
| September 1 | Roxana (Fr-JV-V) | 6:00 p.m. Fr 6:00 p.m. JV-V | Home. Freshman lost. Both JV and Varsity won their matches |
| September 3 | Tiger Classic Tournament (V) | tba | Away (Edwardsville) |
| September 4 | Tiger Classic Tournament (V) | tba | Lady Knights went 4-1 at this tournament and ended with a 3rd place finish |
| September 7 | Pinckneyville (Fr-JV-V) | CANCELED | Away |
| September 9 | Belleville West (Fr-JV-V) | 6:00 p.m. Fr 6:00 p.m. JV-V | Home Varsity Lady Knights won 28-26 and 25-13 |
| September 10 | Crossroads Classic Tournament (V) | tba | Away (Effingham) |
| September 11 | Crossroads Classic Tournament (V) | tba | Lady Knights went 5-0 in this tournament to WIN 1st place in the Gold Bracket |
| September 14 | Staunton (Fr-JV-V) | 5:00 p.m. | Away. Freshman lost 21-7 21-11, JV won 25-13 25-13, Varsity also won 25-17 25-18 |
| September 16 | Granite City (Fr-JV-V) | 6:00 p.m. Fr 6:00 p.m. JV-V | Home. Lady Knights Varsity won 25-15 25-6 |
| September 18 | Central (Fr-JV-V) | 11:00 a.m. | Home. Varsity Won 25-15 25-17 |
| September 21 | Freeburg (Fr-JV-V) | 5:00 p.m. | Away. All three levels were victorious Fr. 21-18, 21-17 JV 25-14, 20-25, 15-6 Varsity 25-15, 25-15 |
| September 25 | St. Francis Borgia and Rock Bridge (V) | 10:00 a.m. | Away. Varsity won against Borgia in 5 games. 21-25 25-21 21-25 25-22 20-18. Lady knights then lost to Rock Bridge in 4 games 11-25 25-21 18-25 20-25 |
| October 1 | Metro East Classic Tournament (V) | tba | Away (Belleville East) |
| October 2 | Metro East Classic Tournament (V) | tba | Away (Belleville East) |
| October 5 | Gibault (Fr-JV-V) | 5:00 p.m. | Away |
| October 11 | O’Fallon (Fr-JV-V) | 6:00 p.m. Fr 6:00 p.m. JV-V | Home |
| October 12 | Althoff (Fr-JV-V) | 5:00 p.m. | Away |
| October 14 | Highland (Fr-JV-V) | 6:00 p.m. Fr 6:00 p.m. JV-V | Home ( Senior Night) |
| October 16 | Cor Jesu (Fr-JV-V) | 11:00 a.m. Fr 11:00 a.m. JV-V | Away |
| October 18 | Edwardsville (Fr-JV-V) | 6:00 p.m. Fr 6:00 p.m. JV-V | Home |
| October 22 | Quincy Notre Dame Tournament (V) | tba | Away |
| October 23 | Quincy Notre Dame Tournament (V) | tba | Away |